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Lissencephaly Therapy Options at NAPA Centre

Sep 08th, 2023 | by Pauline Chuang

Pauline Chuang

September 08th, 2023

What is Lissencephaly?

Lissencephaly is a rare brain malformation that affects an estimated 1 in 40,000 to 60,000 infants born. It is characterized by smooth brain surfaces lacking folds and grooves called gyri and sulci, which usually develop during pregnancy. Gyri and sulci play a crucial role in the brain by dividing different areas of the brain and expanding its surface area, which enhances cognitive capabilities.

What Are Some Challenges Children With Lissencephaly May Face?

There are more than 20 types of Lissencephaly. Most fall into two main categories:

  • Classic Lissencephaly (Type 1)
  • Cobblestone Lissencephaly (Type 2)

What Causes Lissencephaly?

Lissencephaly can be caused by a genetic mutation or non-genetic causes. Genetic mutations can be inherited or occur randomly. Some common gene mutations associated with lissencephaly are: LIS1, RELN, DCX, ARK, and TUBA1A. Lissencephaly can also be caused by viral infection during pregnancy and lack of oxygen to the fetal brain.

What Are Some Challenges Children With Lissencephaly May Face?

What Are Some Treatment Options for Lissencephaly?

There is currently no cure for Lissencephaly. However, a multidisciplinary approach can help children reach their fullest potential. Physiotherapy may focus on improving mobility, muscular strength, coordination, and endurance. Occupational therapy may target improving upper limb strength, upper extremity function, and posture to support activities of daily living, such as dressing. Speech and language pathology may support increasing speech intelligibility (i.e., ability to be understood) and developing expressive and receptive language.

About the Author

As a creative and dedicated physiotherapist, Pauline always strives to create a supportive environment for kids to develop the confidence and competence to reach their goals. She believes in making therapy fun, interactive, and individualised so that it is enjoyable and meaningful to each child. You can spot Pauline at NAPA with the biggest smile, colorful socks, and contagious enthusiasm & positivity.

About NAPA Centre 

NAPA Centre provides paediatric therapy services to children diagnosed with lissencephaly. Learn more about treatment options in this blog post.NAPA specialises in working with children with physical and neurological delays. In addition to working with children with more common diagnoses such as cerebral palsy and Down syndrome, NAPA has a special interest and expertise with children with rare, multiple and complex conditions. NAPA Centre’s Intensive Model of Therapy (IMOT) is world-renowned, and one of the leading clinics in Australia for paediatric therapy programs with a large multi-discliplinary team of Occupational Therapists, Physiotherapists and Speech Therapists all working together. Families routinely travel from all parts of Sydney, the NSW region, from across Australia and even from the Australasian region to access NAPA’s unique and effective programs for their children.

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